PFAS (per- and polyfluoroalkyl substances) measurement context
EPA Method 533: the PFAS are concentrated from the sample on a weak anion exchange solid phase extraction cartridge and measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), with isotope-labeled standards added to each sample for quantitation (isotope dilution). The PFAS listed in the method, including PFOA and PFOS, are reported in ng/L. The method is for drinking water. Other regulated organic chemicals
Provide the compound list
A class name does not establish every target included. Specify the compounds, applicable drinking-water program and reporting limits; use the prescribed bottle and handling plan for the scope.
Include the complete project requirement
Provide the matrix, target analytes, required method, fraction, units and reporting limits. Include the permit or monitoring instructions where results will support a regulatory submission. Naming this method does not establish blanket compliance eligibility.
Resolve collection before sampling
Use the bottle, preservation and delivery instructions assigned to the agreed scope. Identify each location and collection time, and document any deviation. The final analytical plan must fit the submitted material and its intended use.
Related testing & guidance
Technical & service references
Vanguard service detailsSource review: November 8, 2026. The agreed method and project scope govern the testing.