6PPD-quinone measurement context
EPA draft Method 1634, LC-MS/MS: an isotope-labeled 6PPD-quinone standard is added to the sample, the sample is passed through a solid phase extraction cartridge, and the 6PPD-quinone is eluted with acetonitrile and measured by liquid chromatography with tandem mass spectrometry, quantified by isotope dilution. 6PPD-quinone forms in the environment from 6PPD, an additive in vehicle tires; the method is written for stormwater and surface water. Reported in ng/L. Offered for water samples.
Confirm matrix and regulatory context
Environmental water, wastewater and companion solids need explicit applicability review. SW-846 and Clean Water Act methods are not automatically interchangeable for permit reporting.
Include the complete project requirement
Provide the matrix, target analytes, required method, fraction, units and reporting limits. Include the permit or monitoring instructions where results will support a regulatory submission. Naming this method does not establish blanket compliance eligibility.
Resolve collection before sampling
Use the bottle, preservation and delivery instructions assigned to the agreed scope. Identify each location and collection time, and document any deviation. The final analytical plan must fit the submitted material and its intended use.
Related testing & guidance
Technical & service references
Vanguard service detailsSource review: November 8, 2026. The agreed method and project scope govern the testing.